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diagnosis pediatrics leukemia 21hydroxylasedeficiency 21ohd anemia aplastic childhood chronic clinical cll dermatology differential endocrinology genetics immunization leser lesertrelat lymphocytic management
Leser–Trélat Sign on Physical Exam Acute onset of multiple seborrheic keratoses, often a paraneoplastic sign of malignancy. #Leser
PhysicalExam #clinical #video ... #skin #dermatology ... #oncology
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 Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Hypocellular bone marrow ... Direct Damage to Marrow ... Headaches • Pale skin ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... lymphocyte > 5000/microL ... AIHA • Bone marrow ... diagnosis #workup #oncology ... #hematology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
cold & mottled skin ... Labia major & minor ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... endocrinology #peds
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone marrow ... Blood and Bone marrow ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
invade URT & via hematologic ... causes CNS and hematologic ... that persists as skin ... #Immunization #peds ... #pediatrics #pathophysiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone marrow ... just beneath the skin ... Hypercellular marrow ... Syndromes #diagnosis #hematology ... #oncology
Pediatric Parasomnias and Nightmares: Pathogenesis and clinical findings Parasomnias - Micro-arousal episodes during SWS -> Intense activation of
Parasomnias - Micro-arousal ... Speech • Flushed skin ... Nightmares #Pediatrics #Peds ... #pathophysiology
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