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Monkeypox

What?
Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus
Viral zoonotic disease that is
disease that is caused ... 28 days - Skin ... of the systemic symptoms ... bleeding, or other symptoms ... visual acuity Skin
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
URT inflammation causes ... severe swelling causes ... hemorrhagic rash; symptoms ... that persists as skin ... non-specific viral symptoms
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
aldosterone Causes ... : Most Common Causes ... Tuberculosis: can cause ... Androgens: • Symptoms ... patches on the skin
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... trigger - Direct skin ... and duration of symptoms ... 50% of patients Skin ... angioedema Other symptoms
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... for secondary causes ... eosinophilia (common causes ... organ-specific signs or symptoms ... (eg, skin or esophageal
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
hypotension - Nausea ... nervous system symptoms ... disorders: - Pale skin ... Headache, visual symptoms ... Insufficiency #Signs #Symptoms
Differentiating Features Between Central and Peripheral Cyanosis

Mechanism - Arterial destauration
Sites - Skin, mucous membrane of oral
destauration Sites - Skin ... therapy - Pulmonary cause ... Sites - Only skin ... Comparison #Signs #Symptoms
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
hyperglycemic crises ... diabetes Key signs/symptoms ... hypovolemia (dry MM, skin
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
intestines, extremities Skin ... (Skin and Mucosa ... arrest GI (>40%): Nausea ... anaphylaxis #signs #symptoms
Differential Diagnosis and Evaluation of Hyponatremia:
1) Identification of onset (acute vs. chronic)
2) Presence of symptoms (HA,
2) Presence of symptoms ... (HA, nausea, confusion ... status (edema, JVD, skin