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diagnosis treatment rheumatology signs differential druginduced hematology inflammatory pathophysiology sle activation anemia aplastic comparison complications dil henochscholeinpurpura hhv8 hsp iga
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... • Langerhan cells ... keratinocytes release cytokines ... hair follicles -> causes ... diagnosis #signs #symptoms
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... constitutional symptoms ... Discontinuation of causal ... 40, F:M 9:1 • Clinical
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
pro-inflammatory cytokines ... disease • Systemic lupus ... Clinical Presentation ... SJIA], systemic lupus ... #Diagnosis #Management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... → cytokines to ... renal failure Clinical ... are not caused ... skin (16-32%): lupus
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Summary Causes ... Immobilization - Crush ... Dermatomyositis Clinical ... : • Triad of symptoms
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... and petechiae Causes ... • Improve the symptoms ... hematology #diagnosis #management
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
Pathogenesis and Clinical ... various inflammatory cells ... Interleukin 8 (IL8) - cytokine ... nephrotic/nephritic syndrome ... Diagnosis #Signs #Symptoms
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy Presentation:
Bell's Palsy - Diagnosis ... - Atypical Clinical ... systemic signs (rash ... Imaging (if atypical symptoms ... CNS inflammatory cause
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... Syndrome (KICS) ... Working Case Definition ... Symptoms: Fatigue ... #diagnosis #management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Constitutional symptoms ... NPSLE rare, Malar rash ... Discontinuation of causal ... diagnosis #treatment #management
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