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diagnosis differential dermatology dermatomyositis management symptoms vasculitis allergy anaphylaxis antimda5 antimda5dm antinxp2 antinxp2dm arteritis autoimmune classification gca giantcell manifestations myopathy
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... ulcerations • Skin ... Dermatomyositis #rheumatology
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
tongue and lips - Skin ... : urticarial rash ... Gastrointestinal - Nausea ... abdominal cramps Neurologic ... Diagnosis #Allergy #Signs
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 Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... tract, and often causes ... mucositis - Rash ... purpura: strong sign ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... , neurologic, and ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... systemic sx + signs ... required due to skip ... them, but urgent rheumatology ... GCA #Temporal #Signs
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... statins - probably caused
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