Manifestations of Anaphylaxis by Body System
Dermatologic/mucosal
- Eyes: periorbital swelling/erythema, injected conjunctiva, tears
- Oral mucosa: angioedema of the tongue and lips
- Skin: urticarial rash, pruritus or flushing, morbilliform rash, piloerection, angioedema
Respiratory
- Lower airway: bronchospasm with wheezing or cough, chest tightness, tachypnea, decreased peak expiratory flow, cyanosis, respiratory collapse/arrest
- Upper airway: sensation of throat constriction; dry cough; difficulty breathing, swallowing, speaking; changes in voice; stridor; cyanosis; respiratory collapse/arrest
Cardiovascular
- Early: tachycardia, diaphoresis, delayed capillary refill, hypotension
- Late: bradycardia, shock, T-wave inversion and ST depression in multiple leads, cyanosis, cardiac arrest
Gastrointestinal
- Nausea, vomiting, diarrhea, abdominal cramps
Neurologic
- Throbbing headache, dizziness, lightheadedness, confusion, tunnel vision, loss of consciousness
General
- Anxiety, feeling of impending doom, metallic taste, paresthesia in extremities, malaise, weakness
In children: sudden behavior changes, irritability, cessation of play
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