Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa: angioedema of the tongue and lips - Skin: urticarial rash, pruritus or flushing, morbilliform rash, piloerection, angioedema Respiratory - Lower airway: bronchospasm with wheezing or cough, chest tightness, tachypnea, decreased peak expiratory flow, cyanosis, respiratory collapse/arrest - Upper airway: sensation of throat constriction; dry cough; difficulty breathing, swallowing, speaking; changes in voice; stridor; cyanosis; respiratory collapse/arrest Cardiovascular - Early: tachycardia, diaphoresis, delayed capillary refill, hypotension - Late: bradycardia, shock, T-wave inversion and ST depression in multiple leads, cyanosis, cardiac arrest Gastrointestinal - Nausea, vomiting, diarrhea, abdominal cramps Neurologic - Throbbing headache, dizziness, lightheadedness, confusion, tunnel vision, loss of consciousness General - Anxiety, feeling of impending doom, metallic taste, paresthesia in extremities, malaise, weakness In children: sudden behavior changes, irritability, cessation of play #Diagnosis #Allergy #Signs #Symptoms #Anaphylaxis #OrganSystems #Manifestations