19 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
edgarvlermamd #Potassium ... KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... Fluids Shift potassium ... intracellularly: • Insulin ... LouLectures #Hyperkalemia ... #nephrology
Insulin and analogues onset of action, peak times and duration.

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#pharmacology #table #comparison
Insulin and analogues ... www.instagram.com/rxnotes for more ... #pharmacology #table ... #comparison #dosing ... #medications #halflife
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #treatment #pharmacology ... #table #comparison ... #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... paralysis - Insulin ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Thyrotoxicosis Medications ... MatthewHoMD #Hypokalemia ... Diagnosis #Algorithm #nephrology ... #low #potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... paralysis - Insulin ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Metolazone) 5) Potassium-sparing ... nephron #diuretics #pharmacology ... #nephrology #medications
Pharmacokinetics of commonly used diuretics medications in CKD, Cirrhotic Ascites, and Heart Failure
 • Furosemide
 •
used diuretics medications ... Spironolactone MCW Nephrology ... #diuretics #pharmacology ... Pharmacokinetics #halflife #comparison