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diagnosis immunology management c5c9deficiency catheter crbsi gonorrhea humoral immunity infection primarycare sepsis septic septicshock shock stds stis
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... pathogens Bacterial ... activation -> Complement ... #pathophysiology
Gonorrhea: Pathophysiology - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... eradication of pathogen ... Pathogen cleared ... activation of complement ... #Gonorrhea #Pathophysiology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
produced from pathogens ... (bacteria, viruses ... Opsonization: Abs coat pathogens ... Neutralization: Abs bind to pathogen ... Humoral #Immunity #pathophysiology
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
catheter-related bloodstream ... infection - Management Algorithm ... Persistent fever and/or bacteremia ... • Resistant pathogens ... #catheter #bloodstream
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
• Pathophysiology ... NETs), cytokines, complement ... abdomen, GU tract, bloodstream ... • Pathogens: ... Gram-positive/-negative bacteria
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