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immunology c5c9deficiency diagnosis inflammation inflammatory management sepsis septic septicshock shock
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... engulf foreign pathogens ... dead tissue • Complement ... System: opsonize pathogen ... #Inflammation #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
response: The complement ... response to bacterial pathogens ... cascade -> MAC ... tissue -> Fatigue, fever ... #pathophysiology
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... NETs), cytokines, complement ... • Pathogens: ... • Symptoms: Fever
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