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Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
thyroid, Sjogren syndrome ... “dropping head syndrome ... - Kearns-Sayre syndrome ... syndrome - Miller ... immunologic assay - MuSK
Drugs associated with worsening of Myasthenia Gravis (MG):
•	D-penicillamine 
•	Botulinum toxin.
•	Telithromycin
•	Fluoroquinolones 
•	Quinine
•	Magnesium
•	Macrolide antibiotics 
•	Corticosteroids (may cause transient
with worsening of Myasthenia ... prevent prolonged myasthenic ... Patients with MuSK-MG ... higher risk of myasthenic ... muscle-specificreceptortyrosinekinase #AChR #MuSK
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... Syndrome • Botulism
Myasthenia Gravis
Signs, Symptoms and Testing - Likelihood Ratios
Does this patient have myasthenia gravis?
JAMA. 2005 Apr 20;293(15):1906-14.
Myasthenia Gravis ... this patient have myasthenia ... #Diagnosis #Myasthenia ... LikelihoodRatios #PhysicalExam
Curtain Sign - Enhanced Ptosis in Myasthenia Gravis
Because of bilateral eyelid innervation, when the more affected
Enhanced Ptosis in Myasthenia ... Enhanced #Ptosis #Myasthenia ... clinical #video #physicalexam
Ice-pack Test for Myasthenia Gravis - Likelihood Ratio (LR) +24 / -0.16
Ice pack's can be used
Ice-pack Test for Myasthenia ... Icepack #Test #Myasthenia ... #Gravis #physicalexam
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... anti—muscle-specific kinase (MuSK ... antibodies - MuSK-positive ... myasthenia: More ... mild generalized myasthenia
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... Myasthenia gravis ... tumor, and always ask ... eyelid #Ocular #Myasthenia ... #Gravis #PhysicalExam
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Demyelinating Disease (MS ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... , Myasthenia Gravis
Eye Ptosis in Myasthenia Gravis

via @neurologiabr

#Eye #Ptosis #Myasthenia #Gravis #Ocular #clinical #Video #Gaze #Fatigue #PhysicalExam
Eye Ptosis in Myasthenia ... #Eye #Ptosis #Myasthenia ... Gaze #Fatigue #PhysicalExam