161 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
variable degree of weakness ... Limb- proximal weakness ... test - Cogan sign ... - Peek sign ... Severe bulbar weakness
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... #Peripheral #Weakness
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... Myalgia, Muscle weakness ... Signs: Mental ... Hypothyroid #Features #Signs ... #PhysicalExam #Endocrinology
Drugs associated with worsening of Myasthenia Gravis (MG):
•	D-penicillamine 
•	Botulinum toxin.
•	Telithromycin
•	Fluoroquinolones 
•	Quinine
•	Magnesium
•	Macrolide antibiotics 
•	Corticosteroids (may cause transient
with worsening of Myasthenia ... prevent prolonged myasthenic ... higher risk of myasthenic ... because of bulbar weakness
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
spinal cord - Signs ... Ataxia (early sign ... • Gross motor weakness ... (late sign) • ... dexterity loss (early signs
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... or respiratory weakness ... mild to moderate weakness ... or generalized weakness ... and in myasthenic
Myasthenia Gravis
Signs, Symptoms and Testing - Likelihood Ratios
Does this patient have myasthenia gravis?
JAMA. 2005 Apr 20;293(15):1906-14.
Myasthenia Gravis ... Signs, Symptoms ... this patient have myasthenia ... #Diagnosis #Myasthenia
Curtain Sign - Enhanced Ptosis in Myasthenia Gravis
Because of bilateral eyelid innervation, when the more affected
Curtain Sign - Enhanced ... Ptosis in Myasthenia ... #Curtain #Sign # ... Enhanced #Ptosis #Myasthenia
Diagnosis of Myasthenia Gravis - Physical Exam Maneuvers
 • Sustained lateral gaze for seconds to elicit
Diagnosis of Myasthenia ... due to laryngeal weakness ... for neck flexor weakness ... fatigable limb weakness ... BrighamMedRes #Myasthenia
Cushing Syndrome - Signs and Symptoms
Generalized: Weight gain, Slow healing of cuts, Increased risk of infections,
Cushing Syndrome - Signs ... hump Muscular: Weakness ... Cushings #Syndrome #Signs ... Symptoms #diagnosis #endocrinology