28 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
variable degree of weakness ... Limb- proximal weakness ... test - Cogan sign ... - Peek sign ... Severe bulbar weakness
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
or respiratory weakness ... treatment Of ocular ... mild to moderate weakness ... or generalized weakness ... crisis, treatment
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... Myalgia, Muscle weakness ... Signs: Mental ... Hypothyroid #Features #Signs ... #PhysicalExam #Endocrinology
Cushing Syndrome - Signs and Symptoms
Generalized: Weight gain, Slow healing of cuts, Increased risk of infections,
Cushing Syndrome - Signs ... hump Muscular: Weakness ... Cushings #Syndrome #Signs ... Symptoms #diagnosis #endocrinology
Hyperthyroidism – symptoms and signs. 

Symptoms:

Weight loss, Increased appetite, Irritability/behaviour change, Restlessness, Malaise, Stiffness, Muscle weakness,
– symptoms and signs ... Stiffness, Muscle weakness ... ), Sweating Signs ... Hyperthyroidism #Symptoms #Signs ... #Diagnosis #Endocrinology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM weakness ... Myasthenia gravis ... such as cogan sign ... eyelid #Ocular #Myasthenia
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Symptoms: Commonly no signs ... Tiring easily/weakness ... Hyperparathyroidism #diagnosis #endocrinology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
level of muscle weakness ... heliotrope rash, Shaw sign ... , holster sign, ... have significant weakness ... after 2 years of treatment
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Approach To Weakness ... Muscle • Muscle weakness ... Postsynaptic: Myasthenia ... Lack of UMN/LMN signs
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
• Lhermitte’s sign ... Spasm, Cramping, Weakness ... Multiple Sclerosis Treatment ... vision, Diplopia, Weakness ... management #neurology #treatment