35 results
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
variable degree of weakness ... Limb- proximal weakness ... syndrome - Miller ... Gravis Treatment ... Severe bulbar weakness
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... Syndrome • Botulism
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
or respiratory weakness ... treatment Of ocular ... mild to moderate weakness ... or generalized weakness ... crisis, treatment
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... , Myasthenia Gravis ... Neuromuscular #Weakness
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Myalgia, Muscle weakness ... Psychosis, Deafness ... of movement, Deafness ... Carpal timel syndrome ... #PhysicalExam #Endocrinology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Miller Fisher Syndrome ... Treatment: • Plasmapheresis ... Guillain #Barre #Syndrome ... diagnosis #management #treatment
Cushing Syndrome Testing Algorithm
INDICATIONS FOR TESTING:
 • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension)
Testing:
Cushing Syndrome ... Suspected Cushing syndrome ... obesity, muscle weakness ... ARUPLabs #Cushing #Syndrome ... diagnosis #algorithm #endocrinology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... • Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... Postsynaptic: Myasthenia
Cushing Syndrome - Signs and Symptoms
Generalized: Weight gain, Slow healing of cuts, Increased risk of infections,
Cushing Syndrome ... hump Muscular: Weakness ... males) #Cushings #Syndrome ... Symptoms #diagnosis #endocrinology
Ptosis - Differential Diagnosis Framework

Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Horner’s syndrome ... Myasthenia gravis ... to ptosis and weakness ... • Myasthenia gravis ... Myotonic dystrophy • Myasthenia