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diagnosis rheumatology differential management druginduced syndrome activation ana antibodies antinuclear cutaneous dermatology dil erythematosus immune infections infectiousdiseases inflammatory iris macrophage
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... to 1:1 F:M • Clinical ... Constitutional symptoms ... #sle #comparison
Symptoms Distinguishing Groups of Cutaneous Drug Reactions IgE-mediated reactions: • Onset minutes to hours into treatment course
Symptoms Distinguishing ... Groups of Cutaneous Drug ... #Reactions #dermatology ... #clinical #comparison ... #classification
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... disease (MCTD), Drug-induced ... Biliary Cirrhosis, Drug-Induced ... ANA #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Skin Disease Classification ... extremities Drug ... • Symptoms limited
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
belonging to the Mycobacterium ... Growers (Runyon Classification ... Hematologic malignancy ... gastrointestinal symptoms ... (Symptoms, Imaging
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... to 1:1 F:M • Clinical ... Constitutional symptoms ... is rare in DIL, SCLE-DIL ... #DIL #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... Presentation - Systemic Symptoms ... vasculitis, and SLE ... #classification
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
noncompliance • Clinical ... initiation Clinical ... fevers • MAC/NTM ... organizing PNA • Mycobacterium ... Confusion, visual symptoms
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