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diagnosis oncology algorithm basophils chronic cll gap globulin hodgkins leucocytosis leukemoidreaction lymphocytic management markers neutrophil neutrophils pathophysiology protein proteingap wcc
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Acute • Myloid (AML ... , Sudan Black, Auer ... bcr-able (+) ↑ WBC ... #Disorders #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... Neutrophils • Immature/Myeloblasts ... Age: 50-60 • Auer ... - infiltrates (anemia ... #Leukemia #Hematology
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monoblast, & lymphoid ... cell (WBC) count ... Mature WBC: 80- ... LEUCOCYTOSIS WBC ... Transient increase in WBC
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... workup #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Workup: • Full Blood ... platelets - WBC ... Immunohistochemical studies (to differentiate ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Connective tissue disorders ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... #diagnosis #hematology
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