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oncology algorithm aplastic bandemia causes elevatedmcv erythematosus hemolysis lupus macrocytic macrocytosis management myelodysplasia myelodysplastic pathophysiology sle systemic wbc
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... (Normal) Differential ... Tissue damage • Leukemia ... diagnosis #neutrophil ... #WBC #CBC #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Normal Blood Smear ... Hypersegmented Neutrophils ... - Low RBC Folate ... Myelodysplastic Syndromes ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... • Immature/Myeloblasts ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(hypogranular neutrophils ... cells appear normal ... count with differential ... • Peripheral blood ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
(MDS) (normal or ... virus (EBV) • Leukemia ... result from low blood ... #oncology #hematology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... Hodgkin lymphoma and leukemia ... #Rheumatology
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