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oncology causes workup algorithm apl aplastic auer bloodsmear chronic clinical cll disorders elevatedmcv erythematosus hemolysis lupus lymphocytic macrocytic macrocytosis management
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... on the left Myeloblast ... (Normal) Differential ... diagnosis #neutrophil ... #WBC #CBC #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... • Pernicious Anemia ... #Macrocytic #Anemia ... #Causes #Hematology
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... She was diagnosed ... blood smear showed ... #Clinical #Path ... #Smear #Microscopy
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 Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... • Immature/Myeloblasts ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... • Peripheral blood ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... (MDS) (normal or ... virus (EBV) • Leukemia ... result from low blood ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral ... blood smear, HIV ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... cytometry • Peripheral ... smear: Smudge cells ... • Neutropenia, anemia ... #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... Hodgkin lymphoma and leukemia ... #Rheumatology
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