13 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... for specific symptoms ... organ-specific signs ... or symptoms (eg
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... Positive Coombs testing ... post infectious setting ... Monoclonal IgM Includes Disorders
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider RBC membrane disorder ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... anaemia, ataxia ... - Coagulation disorder ... differential #diagnosis #signs ... #symptoms #nutrition
Pulmonary Hypertension Groups - WHO Classification
Group I - Vascular remodeling of pulmonary arteries
 • Idiopathic, HIV,
connective tissue disorders ... Sarcoidosis, chronic hemolytic ... anemia, thyroid ... disorders, sickle ... Symptoms of right
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... pylori test (GI symptoms ... changes), high MCV anemia ... Diagnosis #Causes #Workup
Post-Transplantation Lymphoproliferative Disorders (PTLD)
Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Lymphoproliferative Disorders ... immunosuppression in the setting ... Conditioning regimen Signs ... EBV viral load, signs ... Diagnosis and classification
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
disorders • Selective ... autism spectrum disorder ... musculoskeletal symptoms ... Psychiatric symptoms ... contribute to nonimmune hemolysis
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
recessive blood disorder ... with severe pain, lasting ... of the baseline anaemia ... Crisis #Features #Signs ... #Symptoms
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... ingestion • B symptoms ... -95% of cases) Classification ... Hodgkin Lymphoma Workup