18 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... Treatment Algorithm ... #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... clinical manifestations ... Hypereosinophilia #Syndrome ... #diagnosis #hematology ... #differential #
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
significant: > 10% Band ... Band neutrophils ... to right with bands ... appreciate the value of band ... neutrophil #WBC #CBC #hematology
Scleroderma Like Conditions - Differential Diagnosis
Eosinophilic Fasciitis:
 - Orange peel induration (peau d'orange) of proximal extremities
Like Conditions - Differential ... with sparing of hands ... the mainstay of treatment ... #Scleroderma #Differential ... comparison #table #dermatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
eruption that may ... Resolution > 15 days Differentials ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
myopathy • Anti MAG ... to cold IgG • Lupus ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... - Hepatitis, eosinophilic ... aplastic anemia Treatment ... Anemia #oncology #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Clinical Features ... Erythematosus #Diagnosis #Rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... Rarely dominate the clinical ... reticularis Differential ... • Goodpasture syndrome ... rash #diagnosis #rheumatology