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diagnosis erythematosus sle vasculitis ana antinuclear champs complement criteria cryoglobulins eularacr hypocomplementemia low management mnemonic myopathy myositis patterns sjogrens types
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Clinical Domains ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... Highly specific antibodies ... #diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... Atypical HUS, autoimmune ... antiphospholipid syndrome ... Lupus Erythematosus ... #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... lupus erythematosus ... diagnosis #types #classification ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Skin Disease Classification ... permanent alopecia Differential ... #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia ... Adenocarcinoma Treatment ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ANCA +MPO) • Cryoglobulinemic ... lupus erythematosus ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology ... #classification
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... RP-ILD), dermato-rheumatologic ... • Conduction system ... Myositis #Myopathy #rheumatology ... #differential #
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