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diagnosis management disease erythematosus sle agglutinin anemia antinuclear behcet champs cold complement criteria cryofibrinogenemia cryoglobulins eularacr hemolytic hypocomplementemia low mnemonic
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... lupus erythematosus ... diagnosis #types #classification ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... likely it will be clinically ... SLE), Sjogren's Syndrome ... #rheumatology #diagnosis ... #differential
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Clinical Domains ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... Highly specific antibodies ... #diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... Atypical HUS, autoimmune ... antiphospholipid syndrome ... Lupus Erythematosus ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
lupus erythematosus ... LFT • ESR • ANA ... ) pattern: antibodies ... #rheumatology # ... classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Skin Disease Classification ... permanent alopecia Differential ... #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... Nephrogenic DI Hematologic ... 7%, Cryoglobulinemia ... Adenocarcinoma Treatment ... #Rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Immunotactoid GN & Cryoglobulinemic ... (Cryoglobulinemic ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... occasional oligoclonal bands ... + MPO) Cryoglobulinemic ... Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... malignancies, vasculitis ... processes: • Systemic ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
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