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diagnosis differential classification symptoms syndrome anemia antibody arteritis arthritis common cvid gca giantcell hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology joint leukostasis
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... → Systematic screening ... Anemia #diagnosis #management ... #treatment #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
, erythema and WBC ... noninflammatory Signs ... effusion with few WBCs ... weeks) Can Be Caused ... Diagnosis #MSK #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
: Pneumonia • Autoimmune ... hemolytic anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
sx + signs/sx of ... identifies 85 to 95% of cases ... them, but urgent rheumatology ... GCA #Temporal #Signs ... Symptoms #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... central nervous system ... purpura: strong sign ... Lab Tests: • CBC ... differential #diagnosis #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Immunosuppression • Autoimmune ... platelets - WBC ... classification #hematology ... #oncology #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
papules and Gottron sign ... ) • Shawl sign ... • Conduction system ... statins - probably caused ... Myositis #Myopathy #rheumatology
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