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diagnosis differential anemia hemolytic oncology agglutinin algorithm atlas bloodcell causes classification cold common cvid hemeonc hemophagocytic hepatitis hlh hodgkins hypogammaglobulinemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... usually IgM) (e.g. primary ... • Intrinsic RBC ... differential #diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... : Cold autoimmune ... IgM associated lymphoma ... Malignant lymphoma ... differential #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... disorder or lymphoid ... - Monoclonal - Lymphoid ... Blood smear - RBC ... #hematology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Autoimmune: ... Autoimmune hepatitis ... lung CA, lymphoma ... > 2 • NASH, Chronic ... diagnosis #algorithm #hepatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... lymphoma (Richter ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... hepatitis • Lymphoma ... • Nodules • Lymphoid ... hemolytic anemia ... hypogammaglobulinemia #immunology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
assessment+++ Primary ... lymphoma, B-cell ... solid cancers • Autoimmune ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
biliary cirrhosis ... • B cell lymphoma ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... platelets - WBC ... Treatment • Early ... classification #hematology ... #oncology #management
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