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diagnosis management chronic cll leukemia lymphocytic workup anemia aplastic classification differential erythematosus gammopathies hemeonc hodgkins lupus lymphoma mgus monoclonal multiple
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Left Shift: • Cell ... precursors" • Stab cell ... on the left Myeloblast ... #CBC #hematology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Management Summary Clinical ... marrow plasma cells ... plasma clonal cell ... is also >100 CMC ... Diagnosis #Management #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
lymphocytes, smudge cells ... immunophenotype Clinical ... Vmphocytosis on routine CBC ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Cr >2 mg/dL or CC ... 40 ml/min A - Anemia ... marrow plasma cell ... MGUS #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... number of CD34+ cells ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... platelets - WBC ... classification #hematology ... #oncology #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Malignancy (e.g. hematologic ... Angioimmunoblastic T-cell ... titers > 1:80 • CBC ... : • Chronic B-cell
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... • No CRAB - no anemia ... • CBC + diff • ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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