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differential rheumatology management oncology syndromes arthritis classification erythematosus hiv leukemia lupus systemic thrombocytopenia vasculitis acute aids approach babesia babesiosis barre
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
procedures - Infection ... decreased PLT count: CBC ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... #Causes #Workup
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Chorioretinitis • Diagnosis ... - Compatible syndrome ... nodules, may also see ... #causes #radiology ... #neurology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... Neutrophils • Immature/Myeloblasts ... #Leukemia #Hematology ... #Oncology #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... APS), Secondary prevention ... #CNS #neurology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... weeks without infection ... Lymphocytosis on CBC ... #workup #oncology ... #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
CNS Infection in ... - Differential Diagnosis ... Antimicrobial treatment ... Demyelinating disease ... caused by the JC
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... nervous system (CNS ... and treatment can ... nasal squamous cell ... #neurology #noninflammatory
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... Drugs, Unknown cause ... Treatment: •
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... fibromyalgia) • Infections ... Malignancy (e.g. hematologic ... and CNS • Headache ... titers > 1:80 • CBC
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
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