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antibiogram coverage management overview review sensitivities antifungal spectrum table oncology clinical diagnosis echinocandins hematology resistance susceptibilities 8as amikacin aminoglycosides amr
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... leukemias > 20% ... Chronic leukemia ... Neutrophils • Immature/Myeloblasts ... cutaneous plaques) AML
Antifungal Agents Frequently Used in Leukemia Antibiogram: • Fluconazole • Itraconazole • Voriconazole • Posaconazole • Caspofungin
Frequently Used in Leukemia ... Caspofungin • Anidulafungin ... #Antifungal #Leukemia ... #antibiogram #pharmacology
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... acute myelogenous leukemia ... (AML) that is most ... Rods #AuerRods #AML
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Echinocandins - Antibiotics ... All are IV only. ... Anidulafungin ... #Pharmacology #Antibiotics ... Caspofungin #Micafungin #Anidulafungin
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
AMB = amphotericin ... ; ANID = anidulafungin ... Echinocandins #Pharmacology
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
, flucytosine; AMB ... amphotericin B; ANI, anidulafungin ... antibiogram #management #pharmacology
MDRO: Multiple Drug Resistant Organism (Stenehjem E et al. Clin Infect Dis. 2016; 63(10): 1273-1280) #AntibioticClassificationSchema #Antibiotics
Stenehjem E et al ... AntibioticClassificationSchema #Antibiotics ... clinical #management #pharmacology
Modified penicillin binding proteins as mechanism of resistance to antibiotics. Penicillin Binding Proteins (Transpeptidases) cross link peptidoglycan
resistance to antibiotics ... - Beta-lactam antibiotics ... - Giving more antibiotic ... Binding #Proteins #AMR ... #PBP #pharmacology
Linezolid (Zyvox) (PO and IV) - Antibiotics Class Overview Mechanism: Oxazolidinone class –unique ribosomal inhibitor (acts on
(PO and IV) - Antibiotics ... Spectrum: covers all ... infections #Pharmacology ... #Antibiotics #Review
Coverage of common antibiotics used in the hospital For empiric coverage, first define the type of infection,
Coverage of common antibiotics ... Dapto, Linezolid Amp-S ... infectiousdisease #antibiotics ... #antibiogram #pharmacology
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