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differential aptt oncology prolonged pt algorithm anemia bleeding blood bruising disseminated gastroenterology hemochromatosis hemostasis intravascular mds myelodysplastic reactions syndromes transfusions
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... #diagnosis #causes ... #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... thrombin inhibitors, heparin ... #hematology #coagulation
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... Anemia #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Anemia • Aplastic ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #Syndromes #diagnosis ... #hematology #oncology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... gingivitis or gingival leukemic ... Acquired: • Heparin ... discern these causes ... #Hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
regarding the diagnosis ... elevated iron indices ... including liver and hematologic ... , hepatic iron concentration ... #management #hepatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... severe thrombocytopenia ... due to marrow aplasia ... #Transfusions #diagnosis ... #management #hematology
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