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differential anemia blood hemolytic management bleeding bruising extravascular mds myelodysplasia myelodysplastic oncology petechiae petechial physicalexam rash syndromes thrombocytosis thromboticthrombocytopenicpurpura transfusion
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... G6PD deficiency) ... #Hemolytic #Intravascular ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... with or without platelet ... #Algorithm #workup ... #hematology #testing
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... recipients w/ IgA deficiency ... false negatives on testing ... #Transfusions #diagnosis ... #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... reflection of intravascular ... hemolysis Platelet ... and decreased platelet ... #Workup #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Causes purpura & ... false negatives on testing ... #Transfusion #diagnosis ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
gingivitis or gingival leukemic ... , disseminated intravascular ... discern these causes ... fibrinogen levels, and testing ... #Hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
primary or secondary hemostasis ... Autoimmune Vasculitis (lupus ... Work Up: • ... #Algorithm #Causes ... #dermatology #physicalexam
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Hairy Cell Leukemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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