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systemic generalized pruritus rheumatology cardiomyopathy erythematosus gap globulin lupus myelodysplasia myelodysplastic nonpalpable palpable protein proteingap purpura restrictive sle thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... Myelodysplastic syndrome ... #Diagnosis #Causes ... #hematology #secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm ... Causes == Primary ... Myelodisplastic syndrome ... #generalized #dermatology ... Diagnosis #Algorithm
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #Diagnosis #hematology ... #nonpalpable #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Diagnosis Algorithm ... Myelodisplastic syndrome ... #generalized #dermatology ... Diagnosis #Algorithm
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... blood count with differential ... #diagnosis #hematology ... #oncology
Restrictive Cardiomyopathy - Diagnosis and Causes Clinical: Dyspnea, Exercise Intolerance, ↑ "Right Sided-Symptoms" (ascites, hepatomegaly, ↑↑peripheral edema) Physical
Sarcoidosis, Primary ... Fibrosis, Hyper-eosinophilc ... Syndrome, Endocardial ... #Causes #differential ... #cardiology #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... lymphoma • Evans' syndrome ... the context of primary ... lymphoproliferative syndrome ... Shrinking lung syndrome
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Connective tissue disorders ... ovarian tumors, lung cancers ... gastric tumors • Hematology ... #diagnosis #hematology
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