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diagnosis hematology differential algorithm anemia pathology rbc atlas bandemia bands bloodsmear bodies causes cbc chart dyspmorphic elevatedmcv hemolytic inclusions key
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
cells within the myeloblast ... eosinophils, & basophils ... Mature WBC: 80- ... #LEUCOCYTOSIS #LEUKEMOIDREACTION ... #BASOPHILS
White Blood Cell Maturation Chart #Pathology #WBC #Maturation #Lineage #Chart #Leukocyte #Myeloid #Myeloblast #Lymphocyte
#Pathology #WBC ... Leukocyte #Myeloid #Myeloblast
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 Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
platelets, persistent WBC ... after initial Rx), basophilia ... Algorithm #hematology #WBC
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Red Blood Cell (RBC ... spur cell), Basophilic ... cell, Other RBC ... Howell-Jolly bodies #RBC
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... diagnosis #neutrophil #WBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Hemoglobin H disease • Basophilic ... Sickle cell, MDS #RBC
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... <13, +/- basophilic ... inclusions in RBC
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
thalassemia, S Lepore • Basophilic ... hypertension • Unusual RBC ... acanthocytes - Consider RBC
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
eosinophilia, basophilia ... Neutrophils • Immature/Myeloblasts
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