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oncology causes anemia chronic classification cll dic disseminated extravascular hemeonc hemolysis hemolytic hodgkins leukemia lymphocytic monoclonal neutrophil paraproteinemias pathophysiology thromboticthrombocytopenicpurpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC ... e.g. lupus, CLL, lymphoma ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #WBC #CBC #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • TMA’s (HUS/TTP ... hydration • RBC ... #Coagulation #diagnosis ... #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... reflection of intravascular ... from ischemia WBC ... count and differential ... #Workup #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... to large cell lymphoma ... Leukemia #oncology #hematology ... #hemeonc #diagnosis ... #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
platelets - WBC ... Immunohistochemical studies (to differentiate ... Treatment • Early ... #hematology #oncology ... #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
cryocrystalglobulin GN -C3 GN • Cast ... +Organomegaly+↑RBC ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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