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hepatology algorithm lfts management oncology abnormal aflp alkaline apml bandemia biliary chemistry cholangitis cirrhosis differentiation enzymes fatty hepatitis injury interpretation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Diagnosis Algorithm ... • Placenta • Leukocytes ... #Elevation #Differential ... #hepatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... #diagnosis #neutrophil ... #WBC #CBC #hematology ... #pathophysiology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... Enzyme Elevation ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Enzyme Elevation ... #diagnosis #algorithm ... #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Neutrophils ... , weight loss, abdominal ... • Immature/Myeloblasts ... #Leukemia #Hematology ... #Oncology #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... nausea, vomiting, abdominal ... infiltration) Differential ... Diagnosis: Viral ... Pregnancy #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... obstruction • ALP ... or higher • Liver ... bile ducts Differential ... #workup #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
magnitude of enzyme elevation ... ALP, alkaline phosphatase ... body mass index; FBC ... Abnormal #Algorithm #Hepatology ... #Differential #
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... ATRA treatment Pathophysiology ... acute febrile neutrophilic ... initiation • Differential ... #management #hematology
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