9 results
hematopoiesis - leukocyte maturation tree

- Amy Chung, MD, MSc @AmyChung 

#hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology
hematopoiesis - leukocyte ... hematopoiesis #leukocytes ... maturation #tree #pathophysiology ... #Hematology #Progenitor ... #Cells #WBC #pathology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholangitis #pathophysiology ... #pbc #psc #hepatology ... #comparison
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... white blood cell (WBC ... Mature WBC: 80- ... LEUCOCYTOSIS WBC ... Transient increase in WBC
Summary table of comparison of the difference between primary biliary cholangitis (PBC) and primary sclerosing cholangitis
Summary table of comparison ... biliary cholangitis (PBC ... #differential #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
) - Summary PBC ... 30-65 years PBC ... Pathophysiology ... bile ducts Differential ... diagnosis #workup #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... • Placenta • Leukocytes ... biliary Cholangitis (PBC ... ALP #Elevation #Differential ... Diagnosis #Algorithm #hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... initiation • Differential ... QD until normal WBC ... diagnosis #management #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
+Organomegaly+↑RBC ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Monoclonal #Differential