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differential causes hemolytic extravascular hemolysis intravascular leukemia myelodysplasia myelodysplastic syndromes testing workup
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... ITP • SLE • CLL ... Syndrome • TTP/HUS ... Heart Valve) #Thrombocytopenia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC) - HELLP ... : Thrombotic thrombocytopenic ... uremic syndrome (HUS ... ) (e.g. lupus, CLL ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... #hematology #testing
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
is of B-cell lineage ... - infiltrates (anemia ... , thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... lineages—erythrocytic ... IDUS) • Immune Thrombocytopenia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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