12 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... 40 ml/min A - Anemia ... @AnnKumfer #MultipleMyeloma ... #MGUS #diagnosis ... #hematology #oncology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Sideroblastic anemia ... iron deficiency anemia ... #Morphology #differential ... #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... ), CLL, Myeloma ... disease #hemolytic #anemia ... #hematology #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... -0/abstract BANDemia ... Degree of bandemia ... bacteremia • Bandemia ... #CBC #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Clinical Presentation ... #oncology #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology ... #oncology #management