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hemolytic atlas algorithm bloodcell causes classification extravascular gap globulin hodgkins key management microscopy monoclonal nomenclature paraproteinemias protein proteingap red testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... agglutin disease ... • Intrinsic RBC ... #diagnosis #hematology ... #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Blood smear - RBC ... ), CLL, Myeloma ... #hemolytic #anemia ... #hematology #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Target Cell RBC ... hemolytic anemia ... #Morphology #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... - Sickle cell anemia ... coagulopathy (DIC) #RBC ... #key #diagnosis ... hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... agglutinins disease ... hypertension • Unusual RBC ... #Anemia #Differential ... #workup #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... +Organomegaly+↑RBC ... anemia due to cold ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... Weight loss • Anemia ... anemia • Pain ... platelets - WBC ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... anemia • Other ... #diagnosis #hematology
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