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diagnosis hematology causes anemia agglutinin cold disease endocrinology eosinophil eosinophilia gap globulin gout hyperuricemia mds myelodysplasia myelodysplastic nonpalpable oncology palpable
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Diagnosis Algorithm ... Lymphoproliferative Disorders ... • Acute Myeloid ... Leukemia (CML) - Hemolytic
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... MF) • Chronic myeloid ... #secondary
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... • Screen for secondary ... symptoms (eg, skin ... #Algorithm #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... Consider RBC membrane disorder ... #Anemia #Differential ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... leakage of RBC's secondary ... DIC/TTP/HUS - Hemolytic ... #nonpalpable #dermatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... Secondary Cold ... younger pts) Differential ... significance (MGUS), CLL, Myeloma ... #anemia #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
in primary or secondary ... Vasculitis - Collagen disorders ... deficiency Work ... cryoglobulins • Skin ... #Causes #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... , or all three myeloid ... DDX: Rule Out Secondary ... blood count with differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... MGUS • Multiple myeloma ... gammopathy, and skin ... Connective tissue disorders ... Gap #ProteinGap #differential
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