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algorithm hemolytic myelodysplastic cancer causes cbc clinical cold cutaneous gap globulin manifestations mds neutrophil protein proteingap secondary skin syndrome syndromes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... vera (PV) • Myelodysplastic ... MF) • Chronic myeloid ... leukemia (CML) ... #hematology #secondary
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
syndrome • Myeloid ... appearing during the disease ... course • Significant ... #diagnosis #dermatology ... #oncology #clinical
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... thalassemia, S Lepore • Basophilic ... Agglutination - Cold agglutinins ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... (MGUS), CLL, Myeloma ... #anemia #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... (myeloid)↑ • Mature ... AML (Acute Myeloid ... - infiltrates (anemia ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... , or all three myeloid ... • Aplastic Anemia ... Megaloblastic Anemia ... #hematology #oncology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... 1% Clinically significant ... • Autoimmune diseases ... #WBC #CBC #hematology ... #pathophysiology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
evolution to acute myeloid ... leukemia (AML). ... median age at diagnosis ... tolerate anemia ... #algorithm #hematology
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