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causes myelodysplastic thrombocytosis algorithm bandemia cbc chronic classification clinical cll cold cutaneous disease gammopathy gap globulin hemolytic hodgkins lymphocytic lymphoma
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... Reactive: • Anemia ... Myelofibrosis • Chronic Myeloid ... Leukemia - BWH ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... MF) • Chronic myeloid ... leukemia (CML) ... #hematology #secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... (myeloid)↑ • Mature ... AML (Acute Myeloid ... #Hematology #Oncology ... #Diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... younger pts) Differential ... of undetermined significance ... (MGUS), CLL, Myeloma ... #hematology #diagnosis
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome • Myeloid ... disease course • Significant ... myelodysplastic #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... phenomenon CLL Diagnosis ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
of Undetermined Significance ... cancer for which ... No evidence of anemia ... #hematology #diagnosis ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... , or all three myeloid ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
1% Clinically significant ... Tissue damage • Leukemia ... #differential # ... #WBC #CBC #hematology ... #pathophysiology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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