290 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... vasculitis • Hematologic ... criteria for 1) hematologic ... conditions - multiple myeloma ... peripheral blood myeloid
Hypersegmented neutrophil in a case of acute myeloid leukemia.

Dysplastic neutrophils are typically hypolobated but can be
neutrophil in a case ... of acute myeloid ... AML #Clinical #Hematology ... #Pathology #Smear
Dysplasia in Myelodysplastic Syndrome 
 - 
Dysgranulopoiesis 
 - Dyserythropoiesis 
 - Dysmegakaryopoiesis 

#Dysplasias #MDS #Myelodysplastic
Myelodysplastic Syndrome ... Myelodysplastic #Syndrome ... #Pathology #Hematology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... • Myeloid hemopathy ... most frequent skin ... differential #diagnosis #dermatology ... oncology #clinical #skin
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... Myelodysplastic syndrome ... MF) • Chronic myeloid ... Differential #Diagnosis #Causes ... #hematology #secondary
Priapism 

Secondary Causes:
Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine
Any hyperviscosity syndrome (SCD, leukemia,
Secondary Causes ... hyperviscosity syndrome ... SCD, leukemia, myeloma ... or are zebras (…amyloid
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... Sarcoidosis or Lofgren's syndrome ... Nodosum #Mnemonic #Causes ... Differential #Diagnosis #Dermatology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Myelofibrosis • Chronic Myeloid ... Differential #Diagnosis #causes ... #Platelets #hematology
Staphylococcal Scalded Skin Syndrome (SSSS) 
(aka Ritter disease)

#Staphylococcal #Scalded #Skin #Syndrome #SSSS #Diagnosis #Pediatrics #Dermatology #Ritter
Staphylococcal Scalded Skin ... Syndrome (SSSS) ... Staphylococcal #Scalded #Skin ... #Syndrome #SSSS ... Diagnosis #Pediatrics #Dermatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
lymphoma, melanoma, myeloma ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... Differential #Diagnosis #causes ... #hepatology