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diagnosis oncology gammopathy management multiplemyeloma agglutinin algorithm arteritis clinical cold disease erythematosus gammopathies gap gca giantcell globulin hemolytic lupus multiple
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
for bone marrow biopsy ... (IgG type, M- protein ... concerning for myeloma ... #MGUS #Biopsy # ... diagnosis #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
protein level <3 ... No evidence of anemia ... protein level ( ... insufficiency, Anemia ... protein level <
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... Lymphoma (HCV) • CLL ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... younger pts) Differential ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... • Multiple myeloma ... • Plasma cell ... anemia • Other ... Gap #ProteinGap #differential
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
by bone marrow biopsy ... clonal plasma cells ... marrow; serum protein ... electrophoresis revealed a monoclonal ... #NEJM #clinical
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... very remarkable w/differential ... systemic complaints- anemia ... in literature (NEJM
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
tissue composed of monoclonal ... • No CRAB - no anemia ... IFE, FLC assay Pathology ... • Multiple myeloma ... Diagnosis #Workup #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... pancreatitis, protein-losing ... lymphopenia, low PLT • Anemia ... SLE • Kidney biopsy ... : • Chronic B-cell
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