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diagnosis oncology gammopathy multiplemyeloma agglutinin algorithm cell cold disease gammopathies gap globulin hemolytic management paraproteinemias plasmacytoma proteingap significance undetermined workup
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
for bone marrow biopsy ... (IgG type, M- protein ... concerning for myeloma ... #MGUS #Biopsy # ... diagnosis #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
protein level <3 ... No evidence of anemia ... protein level ( ... insufficiency, Anemia ... protein level <
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... , amyloidosis, solitary ... #Gammopathies #MGUS
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... POEMS (Sclerotic myeloma ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... • Multiple myeloma ... cell leukemia • Solitary ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... younger pts) Differential ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• Biopsy: Solitary ... tissue composed of monoclonal ... • No CRAB - no anemia ... IFE, FLC assay Pathology ... Diagnosis #Workup #Hematology
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