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diagnosis oncology gammopathy multiplemyeloma agglutinin algorithm cell cold disease gammopathies gap globulin management paraproteinemias plasmacytoma proteingap significance workup
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
gammopathy of undetermined ... (IgG type, M- protein ... concerning for myeloma ... #MGUS #Biopsy # ... diagnosis #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
of Undetermined ... protein level <3 ... No evidence of anemia ... insufficiency, Anemia ... #Undetermined #
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... gamma gap (total protein ... , amyloidosis, solitary ... #Gammopathies #MGUS
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Protein/M Component ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
younger pts) Differential ... gammopathy of undetermined ... significance (MGUS ... ), CLL, Myeloma ... #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... • Multiple myeloma ... cell leukemia • Solitary ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• Biopsy: Solitary ... tissue composed of monoclonal ... • No CRAB - no anemia ... IFE, FLC assay Pathology ... Diagnosis #Workup #Hematology
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