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Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
gammopathy of undetermined ... (IgG type, M- protein ... concerning for myeloma ... #monoclonal #gammopathy ... #MGUS #Biopsy #
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... of Undetermined ... No evidence of anemia ... #Monoclonal #Gammopathy ... #Undetermined #
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
younger pts) Differential ... gammopathy of undetermined ... significance (MGUS ... ), CLL, Myeloma ... #anemia #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Protein/M Component ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
: • MGUS • Multiple ... myeloma • Waldenstrom ... cell leukemia • Solitary ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential