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clinical microscopy diagnosis rheumatology smear arm autoinflammatory bloodcells body bonemarrow cd138 crisis ct dysmorphic e1 electronmicroscopy eyelid formation glucagonoma herpes
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... criteria for 1) hematologic ... (12%) • giant cell ... hematopoietic stem cells ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... other forms of myeloma ... primary plasma cell ... Clinical #Smear #Hematology ... #Pathology
Dysmorphic Red Blood Cells on Electron Microscopy This eyeSCANdy image shows dysmorphic red blood cells from the
Dysmorphic Red Blood Cells ... dysmorphic red blood cells ... SEM #clinical #pathology ... #hematology #nephrology
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 Eyelid Melanoma - Despite conservative interventions, the stye had persisted and the skin had become noticeably
Eyelid Melanoma ... the left upper eyelid ... C) #Clinical #Pathology ... #Derm #Eyelid # ... Melanoma #Microscopy #NEJM
Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies). They're difficult to identify
Myeloma: In this ... core, most plasma cells ... #Myeloma #CD138 ... BoneMarrow #Clinical #Pathology ... #Hematology
Glucagonoma-Associated Rash - The rash involved the arms, genitals, and buttocks and had progressed to the
tissue revealed a well-circumscribed ... Clinical #HONC #Derm ... #Pathology #Radiology ... Microscopy #CT #NEJM
Grouped Pustules on an Erythematous Base - On physical examination, grouped, coalescing pustules that had scalloped
multinucleated giant cells ... #Clinical #Derm ... #Pathology #Herpes ... Smear #Microscopy #NEJM
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
vasculopathy, endothelial cell ... → endothelial cell ... rule out other pathology ... Renal #Crisis #rheumatology ... #nephrology #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... patients with EMD myeloma ... IFE, FLC assay Pathology ... • Multiple myeloma ... Diagnosis #Workup #Hematology
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