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Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies). They're difficult to identify as plasma cells because the nucleus is pushed to the periphery (signet ring-like) and the cytoplasm is not visible. CD138 helps (same field is shown). #Myeloma #CD138 #RussellBodies #Body #PlasmaCells #BoneMarrow #Clinical #Pathology #Hematology