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diagnosis management oncology differential anemia aplastic arterial autoinflammatory cholangitis e1 embolism gap globulin hemeonc heparin hit induced leukemia mds myelodysplasia
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... macrocytic anemia, thrombocytopenia ... , myelodysplastic ... or myelodysplastic ... Autoinflammatory #Somatic #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... 65 years PBC Pathophysiology ... Examination: • Skin ... diagnosis #workup #hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... just beneath the skin ... , or all three myeloid ... IDUS) • Immune Thrombocytopenia ... Syndromes #diagnosis #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Heparin Induced Thrombocytopenia ... arterial thrombosis, skin ... ♀, ↑Age, ESRD Pathophysiology ... exposure (prevent skin ... Management #Treatment #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Testosterone - Coumadin skin ... Heparin-induced thrombocytopenia ... Venous #Arterial #pathophysiology ... #hematology #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... infections/fevers • Thrombocytopenia ... • Hypocellular myelodysplastic ... Anemia #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... • Neutrophils (myeloid ... infiltrates (anemia, thrombocytopenia ... CLL -> Invade Skin ... #Leukemia #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
MGUS • Multiple myeloma ... gammopathy, and skin ... Liver disease: Cirrhosis ... gastric tumors • Hematology ... differential #diagnosis #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
standing for: - Thrombocytopenia ... including lymphoma, myeloma ... IGG4 - Hepatic cirrhosis ... cell lymphoma Pathophysiology ... diagnosis #management #rheumatology
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