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Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
Wernicke's Encephalopathy ... - Thiamine Deficiency ... Wernicke's encephalopathy ... of confusion, ataxia ... #deficiency #Wernickes
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency 
Clinical Diagnosis - Caine Criteria (2 out of 4):
Wernicke Encephalopathy ... - Acute Thiamine ... dysfunction and gait ataxia ... #Thiamine #B1 # ... #criteria #neurology
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management
Diagnosis - Caine Criteria (2 of
Wernicke Encephalopathy ... dysfunction (e.g. gait ataxia ... Encephalopathy ... development of Korsakoff syndrome ... #Management #neurology
Wernicke Encephalopathy - Triad

Encephalopathy 
 • Disorientation 
 • Indifference 
 • Inattentiveness 
Ocular motor dysfunction
Wernicke Encephalopathy ... gaze palsies Ataxia ... #Syndrome #Triad ... #Diagnosis #Neurology ... #Thiamine #Deficiency
Korsakoff Syndrome
Clinical Findings:
 • Confabulation: Usually initial phase of the disease
 • Anterograde amnesia: Memory impairment
presentation of Thiamine ... deficiency, consequent ... Encephalopathy ... Encephalopathy ... #neurology #diagnosis
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Thiamine Deficiency ... Syndrome: • Wernicke's ... Encephalopathy ... Ophthalmoplegia - Ataxia ... pathophysiology #wernickes
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... Haemolytic anaemia, ataxia ... Vitamins: • Thiamine ... B1 - Beri-beri, Wernicke-Korsakoff ... syndrome • Riboflavin
Micronutrient Deficiencies After Gastric Bypass
Fat-Soluble Vitamins:
 • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Water-Soluble Vitamins: • Thiamine ... and vomiting, Wernicke's ... encephalopathy ... (encephalopathy, ... ), Korsakoff syndrome
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Hypo-Mg2+ • Vitamin deficiency ... (thiamine) Late ... • Wernicke encephalopathy ... • Vitamin D deficiency ... arrhythmias • Thiamine
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Refeeding Syndrome ... Metabolism -> Decr Thiamine ... - Wernicke-Korsakoff ... Decr Serum K, Mg, Ca ... CNS: Tremors, Ataxia