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diagnosis differential management clinical algorithm cardiology treatment infectiousdiseases rheumatology pathophysiology dermatology hematology infections microbiology signs comparison pocus syndrome peds pulmonary
CARDIAC MYOCYTE POTENTIALS #Pathophysiology #Cardiology #Cardiac #Myocyte #Ventricular #ActionPotentials #Channels #Phases
CARDIAC MYOCYTE ... Cardiology #Cardiac #Myocyte
Cardiac Myocyte Contractile cycle - Ca2+ binds to TnC → TnI is inhibited → conformational change
Cardiac Myocyte ... Pathophysiology #Cardiology #Myocyte
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
ActionPotential #Myocytes
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... • Infectious Causes ... , Typhoid fever, ... Non-Infectious Causes ... differential #diagnosis #causes
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
BPM INFECTIOUS CAUSES ... • Typhoid Fever ... OTHER CAUSES ... There are specific cases ... #differential #causes
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... #bradycardia #Causes
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Overlap Syndrome: Fever ... ANTI-SYNTHETASE SYNDROME: • Fever ... levels 50X ULN • Myocyte ... statins - probably caused
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
pharyngeal erythema, fever ... pharyngeal erythema, fever ... attack meninges -> Fever ... Sudden onset of fever ... pruritic rash, fever
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... or no fever • ... Non-Infectious Causes
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... Brucellosis, Q fever ... vasculitis to cause ... , Factitious fever ... Differential #Diagnosis #causes
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