815 results
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
stroke, Metabolic myopathies ... Dermatomyositis) AKI - Pathophysiology
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... #Inflammatory #myopathies ... #Hypothyroid myopathy ... #Drug-induced myopathies ... Statin-induced myopathy
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... load Drug-induced myopathy ... 5-15% of lupus myopathy ... BostonChiefs #Myositis #Myopathies ... #myopathy #differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... • Metabolic myopathies ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Metabolic Myopathies ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Idiopathic Inflammatory Myopathies ... idiopathic inflammatory myopathies ... Any inflammatory myopathy ... Inflammatory myopathy ... #Inflammatory #Myopathies
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... → Inflammatory myopathies ... Statin-induced myopathy ... - Necrotizing myopathy
Waddling (Myopathic) Gait on Physical Exam

Myopathic gait, also known as waddling gait, is caused by muscle
Waddling (Myopathic ... Physical Exam Myopathic ... #Waddling #Myopathic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
proximal weakness Myopathy ... mediated necrotizing myopathy ... • Metabolic myopathies ... certain drug-induced myopathies