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diagnosis neurology causes algorithm rheumatology clinical inflammatory myopathies endocrinology peds signs symptoms treatment comparison dermatomyositis geriatrics hypothyroid myositis pathophysiology physicalexam
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
#ESR #CK #Differential ... diagnosis of myopathy ... Dermatomyositis #muscle weakness ... #Hypothyroid myopathy ... Statin-induced myopathy
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... #myopathy #differential
Idiopathic Inflammatory Myopathies - Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... #Idiopathic #Myopathy ... #Comparison #Managment ... #Rheumatology #Differential
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Proximal Muscle Weakness ... Mimic Inflammatory Myopathy ... Mitochondrial myopathy ... MuscleWeakness #Myopathy ... mimics #diagnosis #differential
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Elevation (Pain > Weakness ... Critical Illness Myopathy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... #Elevated #CK #differential
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... • Inflammatory myopathy ... Statin-induced myopathy ... #diagnosis #management
Neurological Patterns of Weakness • Hemispheric lesion • Brainstem lesion • Spinal cord lesion • Polyneuropathy
Neurological Patterns of Weakness ... Polyneuropathy • Myopathy ... Neurology #Patterns #Weakness
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm With Sensory Changes:
of Peripheral Weakness ... Sensory Changes - Differential ... • No Objective Weakness ... Oculomotor • Myopathy ... Sensory #Neurology #Differential
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
RASH + MUSCLE WEAKNESS ... Any inflammatory myopathy ... Inflammatory myopathy ... Severe proximal weakness ... #dermatology #Myopathy
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Myopathy: ... mediated necrotizing myopathy ... • Metabolic myopathies ... #Differential #
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